发明名称 |
Methods and materials for characterizing and modulating interaction between heregulin and HER3 |
摘要 |
The disclosure provided herein identifies and characterizes the domain in HER3 receptor that interacts with heregulin ligand. Typical embodiments of the invention disclosed herein include HER3 variant polypeptides having amino acid sequences which differ from the native HER3 polypeptide sequence and which have altered affinities for heregulin. Also disclosed herein are methods and materials for identifying compounds that bind to the heregulin binding domain in HER3 as well as methods and materials for modulating the interaction between HER3 and heregulin.
|
申请公布号 |
US7314916(B2) |
申请公布日期 |
2008.01.01 |
申请号 |
US20060406679 |
申请日期 |
2006.04.19 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
SINGER ELIZABETH;LANDGRAF RALF;SLAMON DENNIS J.;EISENBERG DAVID |
分类号 |
C07K14/00;C07K14/71;C07K17/00;C12N1/21 |
主分类号 |
C07K14/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|