发明名称 |
SMRT co-repressors, transcriptional co-repressors that interact with nuclear hormone receptors |
摘要 |
The present invention relates to isolated polynucleotides encoding a family of silencing mediators of retinoic acid and thyroid hormone receptor (SMRT) isoforms, including vertebrate and invertebrate isoforms thereof. The invention also relates to polypeptide SMRT co-repressors encoded by invention SMRT polynucleotides, and to peptide portions thereof that can modulate transcriptional potential of a nuclear receptor. In addition, the invention relates to chimeric molecules and to complexes containing a SMRT co-repressor or peptide portion thereof, to antibodies that specifically bind such compositions, and to methods for identifying an agent that modulates the repressor potential of a SMRT co-repressor. The invention also provides methods for identifying an agent that modulates a function of a SMRT co-repressor; for modulating the transcriptional potential of a nuclear receptor in a cell using the compositions of the invention; and for identifying a molecule that interacts specifically with a SMRT co-repressor. |
申请公布号 |
US7314747(B1) |
申请公布日期 |
2008.01.01 |
申请号 |
US20000522753 |
申请日期 |
2000.03.10 |
申请人 |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES |
发明人 |
EVANS RONALD M.;CHEN J. DON;ORDENTLICH PETER;DOWNES MICHAEL R. |
分类号 |
C12N1/15;G01N33/53;A61K39/395;C07H21/04;C07K14/47;C07K14/72;C07K16/18;C07K19/00;C12N1/19;C12N5/10;C12N15/00;C12N15/09;C12R1/865;C12R1/91;G01N33/15;G01N33/566;G01N33/74 |
主分类号 |
C12N1/15 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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