Granulated concentrate of a bursting substances for compacted formpieces, method of obtaining such concentrate and application thereof

摘要

In a densified disintegrant granulate for tablets, comprising (A) 60-99 wt.% water-insoluble, water-swellable cellulose and optionally other modified water-swellable polysaccharide derivatives, (B) 1-40 wt.% binder(s) selected from (meth)acrylic acid (co)polymers and their salts and (C) 0-7 wt. % liquid surfactant(s) forming a gel with water, the granulate has a moisture conte of 2-8 wt.%. Independent claims are also included for: (i) an alternative form of the disintegrant granules (also having moisture conten 2-8 wt.%), comprising (A) as above and 1-40 wt.% of at least one polymeric binder/surfactant; and (ii) the preparation of either for the granulate by forming a pre-mix of the components to be granulated then densifying the premix, where the premix is adjusted t moisture content of 10-80 wt.%, followed by drying to a moisture content of 2-8 wt.% after compacting and optionally obtaining t required granule size distribution by milling and screening.