TRICYCLIC SULFONAMIDE COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES

摘要

A METHOD OF INHIBITING RAS FUNCTION AND THEREFORE INHIBITING CELLULAR GROWTH IS DISCLOSED. THE METHOD COMPRISES THE ADMINISTRATION OF A COMPOUND CONTAINING A TRICYCLIC RING SYSTEM TO A BIOLOGICAL SYSTEM. IN PARTICULAR. THE METHOD INHIBITS CELLULAR GROWTH IN A MAMMAL SUCH AS A HUMAN BEING. NOVEL COMPOUNDS OF THE FORMULA: (FORMULA)ARE DISCLOSED. ALSO DISCLOSED ARE PROCESSES FOR MAKING 3-SUBSTITUTED COMPOUNDS OF FORMULA 4.0. FURTHER DISCLOSED ARE NOVEL COMPOUNDS WHICH ARE INTERMEDIATES IN THE PROCESSES FOR MAKING THE 3-SUBSTITUTED COMPOUNDS OF FORMULA 4.0.