A VACCINE COMPOSITION COMPRISING AN ANTIGEN, A SAPONIN AND A STEROL

摘要

THE INVENTION RELATES TO A VACCINE COMPOSITION COMPRISING AN ANTIGEN, AN IMMUNOLOGICALLY ACTIVE SAPONIN FRACTION AND A STEROL.IN PARTICULAR THE PRESENT INVENTION PROVIDES A VACCINE COMPOSITION COMPRISING AN ANTIGEN, QS21, AND A STEROL, CHARACTERISED IN THAT THE RATION OF QS21: STEROL IS FROM 1:1 TO 1:100(W/W). ADDITIONALLY PROVIDED IS A VACCINE COMPOSITION COMPRISING AN IMMUNOLOGICALLY ACTIVE SAPONIN AND A STEROL WHEREIN THE ADJUVANT COMBINATION FURTHER COMPRISES A CARRIER OR 3DE-O-ACYLATED MONOPHOSPHORYL LIPID A (3D-MPL).