PHTHALAZINONE DERIVATIVES

摘要

Compounds of the formula (I):wherein A and B together represent an optionally substituted, fused aromatic ring;X can be NRor CRR; if X NRthen n is 1 or 2 and if X = CRRthen n is 1;Ris selected from the group consisting of H, optionally substituted Calkyl, Caryl, Cheterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups;Ris selected from H, hydroxy, amino; or Rand Rmay together form a spiro-Ccycloalkyl or heterocyclyl group; Rand Rare both hydrogen, or when X is CRR, R, R, Rand R, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and Ris selected from H and halo.