TRANSGENIC FLIES EXPRESSING TAU AND AMYLOID PRECURSOR FRAGMENT

摘要

The present invention discloses a transgenic fly that expresses a carboxy terminal fragment of the human amyloid-.beta. precursor protein (APP) and a double transgenic fly that expresses both the fragment of APP and tau prote in. The transgenic flies of the present invention provide for models of neur odegenerative disorders, such as Alzheimer's disease. The invention further discloses methods for identifying genetic modifiers, as well as screening me thods to identify therapeutic compounds to treat neurodegenerative disorders using the transgenic flies.