发明名称 ACID INSULIN PREPARATIONS WITH ENHANCED STABILITY
摘要 FIELD: chemical-pharmaceutical industry, pharmacy. ^ SUBSTANCE: invention relates to a composition comprising Gly(A21),Arg(B31),Arg(B32)-human insulin, at least one chemical substance chosen from polyatomic alcohols and their ester and ethers, at least one preserving agent and water wherein pH of this pharmaceutical composition is in acid region (pH 1-6.8). The claimed composition possesses the enhanced stability and resistance against aggregation in storage, prolonged effect period that provides administration of the claimed composition once for 24 h. ^ EFFECT: improved, enhanced and valuable properties of preparations. ^ 23 cl, 11 tbl, 3 ex
申请公布号 RU2313362(C2) 申请公布日期 2007.12.27
申请号 RU20050100959 申请日期 2003.06.05
申请人 SANOFI-AVENTIS DOJCHLAND GMBKH 发明人 BRUNNER-SHVARTS ANETTE;LILL' NORBERT
分类号 A61K9/08;A61K38/28;A61K9/00;A61K45/08;A61K47/02;A61K47/04;A61K47/08;A61K47/10;A61K47/12;A61K47/14;A61K47/26;A61K47/34;A61K47/36;A61K47/42;A61P3/10 主分类号 A61K9/08
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