发明名称 |
BACKBONE MODIFICATIONS TO MODULATE OLIGONUCLEOTIDE TARGETING IN VIVO |
摘要 |
The present invention provides antisense compounds and methods for modulating the expression of target genes expressed in the kidney. In particular, this invention provides antisense oligonucleotide compounds optimized for targeting nucleic acid molecules expressed in the kidney. Such compounds are shown herein to efficiently modulate the expression of target genes PTEN, SGLT2 and connective tissue growth factor (CTGF) in the kidney.
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申请公布号 |
US2007299028(A1) |
申请公布日期 |
2007.12.27 |
申请号 |
US20070679159 |
申请日期 |
2007.02.26 |
申请人 |
SIWKOWSKI ANDREW M;WANCEWICZ EDWARD;LEEDOM THOMAS A;WATTS LYNNETTA;GUHA MAUSUMEE;MONIA BRETT P;GRIFFEY RICHARD H;GEARY RICHARD S;HENRY SCOTT;LEVIN ARTHUR |
发明人 |
SIWKOWSKI ANDREW M.;WANCEWICZ EDWARD;LEEDOM THOMAS A.;WATTS LYNNETTA;GUHA MAUSUMEE;MONIA BRETT P.;GRIFFEY RICHARD H.;GEARY RICHARD S.;HENRY SCOTT;LEVIN ARTHUR |
分类号 |
A61K31/7088;A61K31/70;A61K48/00;A61P3/00;A61P3/10;C07H;C07H21/00;C07H21/02;C07H21/04;C12N15/11;C12N15/113;C12Q1/68 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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