发明名称 |
Crystalline form III of agomelatine, a process for its preparation and pharmaceutical compositions containing it |
摘要 |
Crystalline form III of agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide is new. The compound is confirmed by powder X-ray diffraction pattern as given in the specification. An independent claim is included for preparation of the crystalline form III of agomelatine, or N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide involves: heating agomelatine at 110[deg]C until fully melted, and then slowly cooled until recrystallization occurs. ACTIVITY : Hypnotic; Tranquilizer; Antidepressant; Gastrointestinal-Gen; CNS-Gen; Cardiovascular-Gen.; Neuroleptic; Muscular-Gen.; Immunomodulator; Eating-Disorder-Gen.; Anorectic; Anticonvulsant; Antidiabetic; Antiparkinsonian; Nootropic; Neuroprotective; Dermatological; Antimigraine; Cerebroprotective; Endocrine-Gen.; Cytostatic; Analgesic; Contraceptive. MECHANISM OF ACTION : Melatoninergic system receptor agonist; 5-HT(hydroxytryptamine)-2C receptor antagonist. No biological data given. |
申请公布号 |
ZA200606454(B) |
申请公布日期 |
2007.12.27 |
申请号 |
ZA20060006454 |
申请日期 |
2006.08.03 |
申请人 |
LES LABORATOIRES SERVIER |
发明人 |
COQUEREL, GURARD;LINOL, JULIE;SOUVIE, JEAN-CLAUDE |
分类号 |
A61K;C07C |
主分类号 |
A61K |
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