METHYLATION MARKERS FOR EARLY DETECTION AND PROGNOSIS OF COLON CANCERS

摘要

Using a combination of analytic methods epigenetic silencing of markers i n cancer have been determined. The cancers are generally those of the gastro intestinal tract including but not limited to esophageal, head and neck, gas tric, pancreas, liver, and colon. The genes can be used for the early detect ion of cancer or can be used to identify adenomas that will likely progress to carcinomas. Therapeutic regimens based on the epigenetic silenced genes c an be chosen and/or monitored. Kits for evaluating epigenetic silencing of t hese genes can be used for detection and monitoring.