发明名称 |
N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors |
摘要 |
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
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申请公布号 |
US2007299107(A1) |
申请公布日期 |
2007.12.27 |
申请号 |
US20070724792 |
申请日期 |
2007.03.16 |
申请人 |
TOSCANO JOHN P;BROOKFIELD FREDERICK A;COHEN ANDREW D;COURTNEY STEPHEN M;FROST LISA M;KALISH VINCENT J |
发明人 |
TOSCANO JOHN P.;BROOKFIELD FREDERICK A.;COHEN ANDREW D.;COURTNEY STEPHEN M.;FROST LISA M.;KALISH VINCENT J. |
分类号 |
A61K31/18;A61K31/381;A61K31/47;A61P9/00;C07C311/16;C07D215/36;C07D333/34 |
主分类号 |
A61K31/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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