QUATERNARY AMMONIUM SALT COMPOUNDS OF SPIROCYCLOPIPERAZINES, PREPARATION METHODS AND USES THEREOF

摘要

Compounds represented by general formula (I), their stereoisomers, tautomers, derivatives, prodrugs or pharmaceutically accepted salts, and their preparation methods or uses for the manufacture of a medicament of analgesics. In which R₁ is selected from H, substituted or unsubstituted phenyl, or substituted or unsubstituted heteroaryl; A selected from bond, or substituted or unsubstituted hydrocarbon radical;R₂, R₃ each other independently is selected from hydrogen or methyl, which linked with the any position of spiro structure; n and m are integer of 0~2, and do not represent 0 at same time; B, D each other independently is lineared or branched alkylene; Y is selected from -CHR₄-, O, S, -S(O)-, -SO₂-, -NR₄ or substituted or unsubstituted phenylene, in which R₄ selected from H, saturated or unsaturated C1-C6-alkyl, substituted or unsubstituted aryl, or heteroaryl substituted methyl or ethyl; X^- is pharmaceutically accepted inorganic or organic anion. These compounds can be used as muscarine receptor (M-receptor) and/or nicotine acetylcholine receptor (N-receptor) agonist or antagonist. These compounds have good analgesic effect without side effect such as addiction.