发明名称 |
Neutral endopeptidase (NEP) and human soluble endopeptidase (hSEP) inhibitors for prophylaxis and treatment of neurodegenerative disorders |
摘要 |
The invention relates to a novel use of known benzazepine, benzoxazepine, benzothiazepine-N-acetic acid and phosphono-substituted benzazepinone derivatives having neutral endopeptidase (NEP) and/or human soluble endopeptidase (hSEP) inhibitory activity. The compounds of the invention are useful for the preparation of pharmaceutical compositions for prophylaxis and treatment of neurodegenerative disorders. The compounds of the invention are known from the European patents EP 0 733 642 and EP 0 916 679, and can be described by the general formula (1) wherein the symbols have the meanings as given above in the description. |
申请公布号 |
ZA200605549(B) |
申请公布日期 |
2007.12.27 |
申请号 |
ZA20060005549 |
申请日期 |
2006.07.05 |
申请人 |
SOLVAY PHARMACEUTICALS B.V. |
发明人 |
WESKE, MICHAEL;IKONOMIDOU, HRISSANTHI;TURSKI, LECHOSLAW A.;ZIEGLER, DIETER |
分类号 |
A61K;A61K31/55;A61P |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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