| 摘要 |
PROBLEM TO BE SOLVED: To provide a preparation in a vesicle-dispersion system enabling dermal administration. SOLUTION: The external preparation for the skin contains (1)α,ε-bis(γ-N-(10-30C)acyl-glutamyl)lysine and (2) a polymer or a copolymer having a phosphorylcholine structure. The acyl group having 10-30 carbons constituting theα,ε-bis(γ-N-(10-30C)acyl-glutamyl)lysine is preferably a lauroyl group, and the polymer or the copolymer having the phosphorylcholine structure is preferably one or more kinds selected from a methacryloyloxyethylphosphorylcholine, a butyl methacrylate-methacryloyloxyethylphosphorylcholine copolymer, a stearyl methacrylate-methacryloyloxyethylphosphorylcholine copolymer, and salts thereof. COPYRIGHT: (C)2008,JPO&INPIT
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