| 摘要 |
PROBLEM TO BE SOLVED: To provide an optically active benzyloxypyrrolidine derivative hydrochloride powder simply and safely in a high yield, and its manufacturing method. SOLUTION: The manufacturing method of the optically active benzyloxypyrrolidine derivative hydrochloride powder comprises two steps, a first step: a conversion step into a hydrochloride where an optically active benzyloxypyrrolidine derivative represented by general formula (1) (wherein R is a group selected from among (i) hydrogen, (ii) a 1-4C alkyl group, (iii) a 1-4C alkoxy group and (iv) a halogen group) is brought into contact with hydrogen chloride in an organic solvent and a second step: an isolation step, for crystallizing from the solution obtained in the first step, where the solution is subjected to crystallization after the molar ratio of hydrogen chloride present in the system to the optically active benzyloxypyrrolidine derivative is adjusted to 0.9-1.2 with or without a concentration treatment. COPYRIGHT: (C)2008,JPO&INPIT
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