发明名称 |
METHODS AND COMPOSITIONS FOR INHIBITING OR REDUCING HAIR LOSS, ACNE, ROSACEA, PROSTATE CANCER, AND BPH |
摘要 |
This invention provides methods of treating androgenetic alopecia (AGA), acne, rosacea, prostate cancer, and benign prostatic hypertrophy (BPH), comprising the step of contacting a subject with a compound or composition capable of decreasing prostaglandin D2 (PGD2) level or activity, a downstream signaling or receptor pathway thereof, or prostaglandin D2 synthase level or activity; methods of stimulating hair growth, comprising the step of contacting a subject with a compound or composition capable of increasing or decreasing the activity or level of a target gene of the present invention, or with a protein product of the target gene or an analogue or mimetic thereof; and methods of testing for AGA and evaluating therapeutic methods thereof, comprising measuring PGD2 levels. |
申请公布号 |
WO2007149312(A2) |
申请公布日期 |
2007.12.27 |
申请号 |
WO2007US14031 |
申请日期 |
2007.06.15 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;GARZA, LUIS;COTSARELIS, GEORGE |
发明人 |
GARZA, LUIS;COTSARELIS, GEORGE |
分类号 |
A61K48/00;A61K8/73 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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地址 |
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