发明名称 |
Strategy for Leukemia Therapy |
摘要 |
The chimeric Bcr-Abl oncoprotein is the molecular hallmark of chronic myelogenous leukemia (CML). In the cytoplasm, the protein transduces a growth signal that is responsible for overexpansion of cells. In the nucleus, the protein induces apoptosis. The invention is a method of treating cancer/killing Bcr-Abl expressing cells by inducing the translocation of Bcr-Abl to the nucleus to activate the apoptotic pathway in cancer cells.
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申请公布号 |
US2007299097(A1) |
申请公布日期 |
2007.12.27 |
申请号 |
US20070771453 |
申请日期 |
2007.06.29 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
WANG JEAN Y.;VIGNERI PAOLO |
分类号 |
A61K31/366;A61K31/519;A61K45/06;A61K48/00;A61K49/00;C07K14/82 |
主分类号 |
A61K31/366 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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