摘要 |
<p>A compound represented by the general formula [I], a pharmaceutically acceptable salt thereof, or a solvate of the compound or the salt; and a pharmaceutical composition, an anti-HIV agent, and an HIV integrase inhibitor, each comprising the compound. [I] wherein each symbol is as defined in the description. The compound has an action of inhibiting the HIV integrase activity, and therefore is useful as an anti-HIV agent or a therapeutic or prophylactic agent for AIDS. By using in combination with other anti-HIV agent such as a protease inhibitor and a reverse transcriptase inhibitor, the compound can act as a more effective anti-HIV agent. Further, because of its high inhibitory activity specifically against an integrase, the compound can act as an agent which is safe for a human body and has few adverse side-effects.</p> |
申请人 |
JAPAN TOBACCO INC.;SATOH, MOTOHIDE;ARAMAKI, HISATERU;YAMASHITA, MASAKI;INOUE, MASAFUMI;KAWAKAMI, HIROSHI;SHINKAI, HISASHI;NAKAMURA, HIROSHI;MATSUZAKI, YUJI;WAMAKI, SHUICHI |
发明人 |
SATOH, MOTOHIDE;ARAMAKI, HISATERU;YAMASHITA, MASAKI;INOUE, MASAFUMI;KAWAKAMI, HIROSHI;SHINKAI, HISASHI;NAKAMURA, HIROSHI;MATSUZAKI, YUJI;WAMAKI, SHUICHI |