CINNAMOYL-PIPERAZINE DERIVATIVES AND THEIR USE AS PAR- I ANTAGONISTS

摘要

The present invention relates to compounds of general formula (I), wherei n: R1 represents halogen, CN or NO2; R2 represents hydrogen or halogen; n re presents 1 or 2; R3 represents phenyl substituted by one or more halogens or C1-C6 alkyls; or a cyclohexyl; as well as the therapeutically-acceptable sa lts or solvates thereof. These compounds are useful as protease-activated re ceptor-1 (par-1) antagonists, particularly in the treatment of thrombosis.