| 摘要 |
PROBLEM TO BE SOLVED: To provide enteric granules in which elution to water is suppressed in a low coating amount, in the enteric granules containing adenosine triphosphate or its pharmaceutically permissible salt as a pharmaceutically effective component, and to provide a method for producing the enteric granules. SOLUTION: The enteric granules comprise raw granules carrying adenosine triphosphate or its pharmaceutically permissible salt as a pharmaceutical effective component or granules containing the raw granules and one or more layers for applying the raw granules, a first enteric layer for applying the raw granules or the granules and a second enteric layer thereon, and the first enteric layer and the second enteric layer each contains hydroxypropylmethyl cellulose acetate succinate (HPMCAS) which are different in dissolution pH and the dissolution pH of HPMCAS of the second enteric layer is lower than the dissolution pH of HPMCAS of the first enteric layer. The method for producing the enteric granules is also provided. COPYRIGHT: (C)2008,JPO&INPIT
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