发明名称 |
Erythromycins and Process for Their Preparation |
摘要 |
14-membered macrolide compounds such as erythromycins are provided with functional groups at the 14- and/or 15-position by providing a 14-membered aglycone template and feeding it to a strain capable of hydroxylating it at the 14 and/or 15 position. The strain may be found by screening, selected from known strains (e.g. Streptomyces eurythermus DSM 40014) or produced by genetically engineering a strain to express a cytochrome P450 enzyme.
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申请公布号 |
US2007299252(A1) |
申请公布日期 |
2007.12.27 |
申请号 |
US20040580781 |
申请日期 |
2004.11.29 |
申请人 |
KENDREW STEVEN G;LILL RACHEL E |
发明人 |
KENDREW STEVEN G.;LILL RACHEL E. |
分类号 |
C07H17/08;C07D313/00;C12P17/08;C12P19/62 |
主分类号 |
C07H17/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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