N-(3,4-DISUBSTITUTED PHENYL)SALICYLAMIDE DERIVATIVE

摘要

A compound represented by the formula (I) or a salt thereof, which is useful as an active ingredient of a pharmaceutical for the prevention and/or treatment of a disease induced by the activation of STAT6 and/or NF-?B. (I) wherein R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP> and R<SUP>4</SUP> independently represent a hydrogen atom, a halogen atom, a cyano group, a nitro group, a C<SUB>1-4</SUB> alkyl group, a halogenated C<SUB>1-4</SUB> alkyl group, or a C<SUB>1-4</SUB> alkoxy group; R<SUP>5</SUP> represents a halogen atom, a cyano group, a C<SUB>1-4</SUB> alkyl group, a halogenated C<SUB>1-4</SUB> alkyl group, or a C<SUB>1-4</SUB> alkoxy group; R<SUP>6</SUP>represents a C<SUB>5-7</SUB> cycloalkyl group, a substituted C<SUB>5-7</SUB> cycloalkyl group, a completely saturated 5- to 7-membered heterocyclic group or a substituted, completely saturated 5- to 7-membered heterocyclic group; X represents a single bond, an oxygen atom, a sulfur atom, NR<SUP>7</SUP>, -O-CH<SUB>2</SUB> or -N(R<SUP>8</SUP>)-CH<SUB>2</SUB>-; R<SUP>7</SUP> represents a hydrogen atom or a C<SUB>1-4</SUB> alkyl group, or together with a substituent in R<SUP>6</SUP> forms a single bond, a methylene group or an ethylene group; and R<SUP>8</SUP> represents a hydrogen atom, a C<SUB>1-4</SUB> alkyl group, or a C<SUB>7-12</SUB> aralkyl group.