| 发明名称 |
PYRIMIDINE NUCLEOTIDE PRECURSOR FOR TREATING SYSTEMIC INFLAMMATION AND INFLAMMATORY HEPATITIS |
| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a preventive agent and a therapeutic agent improving survivorship of systemic inflammatory response syndrome (SIRS) and effective for preventing cell damages. <P>SOLUTION: A pyrimidine nucleotide precursor such as a prodrug derivative (acyl derivative) of cytidine, uridine, orotate or the like, and a uridine phosphorylase inhibitor are singly administered to animals or together with other agents. The agents enhance resistance to bacterial endotoxins, other inflammatory stimuli and inflammatory mediators. <P>COPYRIGHT: (C)2008,JPO&INPIT |
| 申请公布号 |
JP2007332144(A) |
申请公布日期 |
2007.12.27 |
| 申请号 |
JP20070177101 |
申请日期 |
2007.07.05 |
| 申请人 |
PRO NEURON INC |
发明人 |
BORSTEL REID WARREN VON;BAMAT MICHAEL K;HILTBRAND BRADLEY M |
| 分类号 |
A61K31/505;A61K45/00;A61K31/00;A61K31/513;A61K31/515;A61K31/70;A61K31/7042;A61K31/7052;A61K31/706;A61K31/7064;A61K31/7068;A61K31/7072;A61K31/7076;A61K31/708;A61K31/715;A61K38/00;A61K45/06;A61P1/16;A61P17/00;A61P29/00;A61P31/00;A61P31/04;A61P35/00;A61P37/02;A61P37/06;A61P39/02;A61P43/00;C07D239/54;C07H;C07H19/06;C07H19/067;C07H19/10 |
主分类号 |
A61K31/505 |
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