AN IMPROVED PROCESS FOR THE MANUFACTURE OF RABEPRAZOLE SODIUM

摘要

A process for manufacture of amorphous Rabeprazole sodium with mean particle diameter between 10 to 55 mum said process comprising addition of Rabeprazole to aqueous sodium hydroxide; addition of ethyl alcohol to the solution; distillation of solvents from the solution thus obtained till thick mass is obtained; addition of an organic solvent to the residue to obtain a clear solution; addition of this clear solution to an anti- solvent under agitation and isolation of the product.