| 摘要 |
<p>A process for the preparation of valgancyclovir which comprises:
a) reacting a compound of formula 7,
in an aprotic solvent, in the presence of a condensing agent, with a compound of formula 8,
wherein R 1 , and R 2 may be, each independently, hydrogen, an halogen atom or an hydroxyl group; the double bond may either be in the E or Z configuration or a mixture thereof to yield a compound of formula 9
b) mild hydrolysis of compound obtained in a) to give valgancyclovir.</p> |
