Peptide derivatives having beta-secretase inhibitory activity

摘要

Provided are excellent beta-secretase inhibitors, that is, compounds represented by the general formula (1) or prodrugs thereof: wherein A is amino or protected amino; B¹ and B² are each a single bond, alkylene of 1 to 3 carbon atoms, or the like; D is a single bond, -NHCO, or the like; E is -COOH, tetrazole ring, or the like; n is an integer of 1 to 3; m is an integer of 1 to 3; G is hydroxyl, a group represented by the general formula (2), or the like: in which Z is -NH, -Asp-Ala-NH-, -Asp-Ala-, -Asp-NH-, or the like; L is a 5-to 10-membered ring optionally containing a heteroatom and/or unsaturated bond; X is -COOH, tetrazole ring, or the like; Y is hydrogen, -COOH, or the like; and k is an integer of 1 to 4; and R¹, R², and R³ are each alkyl of 1 to 6 carbon atoms, or the like.