发明名称 Substituted hydroxyethylamines
摘要 Disclosed are compounds of the formula and the pharmaceutically acceptable salts thereof wherein the variables G, L, A, W, E, R2, R3, R4, R5, R<SUB>N</SUB>, and R<SUB>c </SUB>are defined herein. These compounds interact with and inhibit the activity of the enzyme beta-secretase. These compounds are therefore useful in treating Alzheimer's disease and other similar diseases. Pharmaceutical compositions and methods of treatment of these diseases are also disclosed.
申请公布号 US7312360(B2) 申请公布日期 2007.12.25
申请号 US20020313849 申请日期 2002.12.06
申请人 ELAN PHARMACEUTICALS, INC.;PHARMACIA & UPJOHN COMPANY 发明人 TENBRINK RUTH;MAILLARD MICHEL;WARPEHOSKI MARTHA
分类号 C07C233/65;A61K31/165;A61K31/166;A61K31/421;A61P9/00;A61P25/16;A61P25/28;A61P43/00;C07C217/64;C07C233/36;C07C233/40;C07C233/66;C07C233/78;C07C271/16;C07C271/20;C07C271/28;C07C309/74;C07C311/09;C07C311/13;C07C323/41;C07C323/42;C07D263/32;C07D263/48;C07D303/36 主分类号 C07C233/65
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