| 发明名称 |
Aggrecanase-1 and -2 peptide substrates and methods |
| 摘要 |
The present invention describes synthetic peptide substrates of the metalloproteases, aggrecanase-1 and/or -2 suitable for assays of enzyme activity. The invention also describes methods using these peptides to discover pharmaceutical agents that modulate these proteases.
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| 申请公布号 |
US7312045(B2) |
申请公布日期 |
2007.12.25 |
| 申请号 |
US20040012797 |
申请日期 |
2004.12.15 |
| 申请人 |
ORTHO-MCNEIL PHARMACEUTICAL, INC. |
发明人 |
FOURIE ANNE M.;KARLSSON LARS;COLES FAWN |
| 分类号 |
C12Q1/37;A61K38/00;A61K38/04;C12N9/64 |
主分类号 |
C12Q1/37 |
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