CD4 MIMIC PEPTIDES AND THEIR USES

摘要

An isolated peptide comprising the sequence (I): TPA-Asn-Leu-His- Phe-Cys-Gln-Leu-Xaa<SUP>a</SUP>-Cys-Lys-Ser-Leu-Gly-Leu-Leu-Gly-Axg-Cys-Xaa<SUP>b-</SUP>Xaa<SUP>c</SUP>- Xaa<SUP>d</SUP>-Xaa<SUP>e</SUP>-Cys-Ala-Cys-Val-NH<SUB>2</SUB>, wherein: TPA represents thiopropionic acid; Xaa<SUP>a</SUP> represents Arg, Lys; Xaa<SUP>b</SUP> represents Ala, Arg; Xaa<SUP>c</SUP> represents a D-amino acid; Xaa<SUP>d</SUP> represents Thr, Ser, Asn; Xaa<SUP>e</SUP> represents phenylalanine or a phenylalanine derivative having the structure (II), where A is absent or represents S, O, NH or CH<SUB>2</SUB>, B is absent or represents a C<SUB>1</SUB> to C<SUB>6</SUB> branched or straight-chain alkyl, and R represents a C<SUB>3</SUB> to C<SUB>6</SUB> alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, cycloalkenyl, cycloheterocyloalkenyl, aryl, or heteroaryl, and the use of the peptide for manufacturing anti-HIV therapeutic or vaccine compositions are disclosed herein.