2 -OXYHETEROARYLAMIDE DERIVATIVES AS PARP INHIBITORS

摘要

A compound of the formula (I): and pharmaceutically acceptable salts thereof, wherein: HetA is a C<SUB>5</SUB> arylene group, wherein the two substituent groups are on adjacent ring atoms, and where the group is further optionally substituted by one halo, amino or C<SUB>1-7</SUB> alkoxy group; Y is -CR<SUP>C1 </SUP>R<SUP>C2</SUP>-(CH<SUB>2</SUB>)<SUB>m</SUB>-, where m is 0 or 1, R<SUP>C1</SUP> is selected from H, CH<SUB>3</SUB> and CF<SUB>3</SUB>, and R<SUP>C2</SUP> is selected from H and CH<SUB>3</SUB>, or R<SUP>C1</SUP> and R<SUP>C2</SUP> together with the carbon atom to which they are attached form the 1,1-cyclopropylene group formula (A): R<SUP>N1</SUP> and R<SUP>N2</SUP> are independently selected from H and R, where R is optionally substituted C<SUB>1-10</SUB> alkyl, C<SUB>3-20</SUB>heterocyclyl and C<SUB>5-20 </SUB>aryl; or R<SUP>N1</SUP> and R<SUP>N2</SUP>, together with the nitrogen atom to which they are attached form an optionally substituted 5-7 membered, nitrogen containing, heterocylic ring; HetB is selected from: (i), where Y<SUP>1</SUP> and Y<SUP>3</SUP> are independently selected from CH and N, Y<SUP>2</SUP> is selected from CX and N and X is H, Cl or F; and (ii), (aa), (bb) Q is O or S.