发明名称 |
ANTIHYPERTENSIVE THERAPY METHOD |
摘要 |
Methods and therapeutic combinations are provided for lowering blood pressure in a subject exhibiting resistance to a baseline antihypertensive therapy with one or more drugs, or a subject having diabetes and/or chronic kidney disease. A method of the invention comprises administering, in some embodiments adjunctively with a modified baseline therapy, a compound of formula (I) as defined herein. A therapeutic combination of the invention comprises a compound of formula (I); at least one diuretic; and at least one antihypertensive drug selected from ACE inhibitors, angiotensin II receptor blockers, beta-adrenergic receptor blockers and calcium channel blockers; wherein the at least one diuretic and/or the at least one antihypertensive drug are present at substantially less than a full dose. |
申请公布号 |
WO2007146900(A2) |
申请公布日期 |
2007.12.21 |
申请号 |
WO2007US70933 |
申请日期 |
2007.06.12 |
申请人 |
GILEAD COLORADO, INC.;GORCZYNSKI, RICHARD, J. |
发明人 |
GORCZYNSKI, RICHARD, J. |
分类号 |
A61K31/422;A61K45/06;A61P7/00;A61P9/00 |
主分类号 |
A61K31/422 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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