METHODS AND COMPOSITIONS FOR THE TREATMENT AND DIAGNOSIS OF DISEASES CHARACTERIZED BY VASCULAR LEAK, HYPOTENSION, OR A PROCOAGULANT STATE
摘要
Disclosed herein are methods for treating a vascular leak disorder, hypotension, or a procoagulant state using angiopoietin-2 (Ang-2) antagonist compounds. Also disclosed are methods for treating a vascular leak disorder associated with high dose IL-2 therapy using angiopoietin-2 antagonist compounds. Methods for diagnosing and monitoring vascular leak disorders, hypotension, or a procoagulant state that include the measurement of Ang-2 polypeptide or nucleic acid levels are also disclosed. Methods for inducing a vascular leak using an Ang-2 agonist are also disclosed.
申请公布号
WO2007033216(A3)
申请公布日期
2007.12.21
申请号
WO2006US35582
申请日期
2006.09.12
申请人
BETH ISRAEL DEACONESS MEDICAL CENTER;SUKHATME, VIKAS, P.;KARUMANCHI, S., ANANTH;PARIKH, SAMIR, M.
发明人
SUKHATME, VIKAS, P.;KARUMANCHI, S., ANANTH;PARIKH, SAMIR, M.