DUAL MOLECULES CONTAINING A PEROXIDE DERIVATIVE, THEIR SYNTHESIS AND THERAPEUTIC USES

摘要

The invention concerns dual molecules corresponding to formula (I): in which: - A represents a molecular residue with antimalarial activity of formula (IIa) or (IIIa) or a residue facilitating bioavailability; - B represents a cycloalkyl group potentially substituted, or B represents a bi- or tricyclic group capable of being substituted, or B represents 2 cycloalkyl groups linked together through either a single bond or an alkylene chain; - m and n represent independently of one another 0, 1 or 2; - R₅ represents a hydrogen atom, an alkyl, cycloalkyl or C₁-₃-alkylene-cycloakyl group; - Z₁ and Z₂ represent an alkyl radical, the group Z₁ + Z₂ + C_i + C_j representing a mono- or polycyclic structure, with one of the Z₁ or Z₂ being able to represent a single bond; - R₁ and R₂, identical or different, represent a hydrogen atom or a functional group capable of increasing hydrosolubility; - R_x and R_y forming together a cyclic peroxide including 4 to 8 links and including 1 or 2 additional oxygen atoms in the cyclic structure, possibly substituted by one or more R₃ groups; as a base or a salt to be added to an acid, as a hydrate or solvate, in racemic form, isomers and their mixtures, in addition to their diastereoisomers and their mixtures. Preparation method and use as medications with antimalarial activity.