CRYSTAL STRUCTURE OF POLO-LIKE KINASE 3 (PLK3) AND BINDING POCKETS THEREOF
摘要
The invention relates to molecules or molecular complexes, which comprise binding pockets of PLK3 or its structural homologues. The invention relates to crystallizable compositions and crystals comprising PLK3. The present invention also relates to a data storage medium encoded with the structural coordinates of molecules and molecular complexes which comprise the PLK3 or PLK3-like ATP-binding pockets. The present invention also relates to a computer comprising such data storage material. The computer may generate a three-dimensional structure or graphical three-dimensional representation of such molecules or molecular complexes. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for, identify and design compounds, including inhibitory compounds that bind to PLK3 or homologues thereof.
申请公布号
WO2007146436(A2)
申请公布日期
2007.12.21
申请号
WO2007US14149
申请日期
2007.06.14
申请人
VERTEX PHARMACEUTICALS INCORPORATED;BROWN, KIERON;CHEETHAM, GRAHAM MT;RENWICK, SUZANNE B;LONG, JOANNA M
发明人
BROWN, KIERON;CHEETHAM, GRAHAM MT;RENWICK, SUZANNE B;LONG, JOANNA M