HOLLOW-FIBER-LIKE ORGANIC NANOTUBE AND PROCESS FOR PRODUCTION THEREOF

摘要

Disclosed is a process which can synthesize an organic nanotube capable of including a functional substance efficiently and free from water, in a simple manner and in a large quantity. The process comprises the steps of: causing the self-assembly of an N-glycoside-type glycolipid represented by the general formula (1) or a peptide lipid represented by the general formula (2) or (3) in a solution by (i) dissolving the N-glycoside-type glycolipid or the peptide lipid in an organic solvent heated to a temperature equal to or lower than the boiling point thereof, then cooling the solution gradually, and allowing the solution to stand at room temperature, (ii) dissolving the N-glycoside-type glycolipid or the peptide lipid in an organic solvent, condensing the solution, and allowing the condensed solution to stand at room temperature, or (iii) dissolving the N-glycoside-type glycolipid or the peptide lipid in an organic solvent heated to a temperature equal to or lower than the boiling point thereof, adding a poor solvent for the N-glycoside-type glycolipid or the peptide lipid to the solution, and allowing the solution to stand at room temperature, thereby producing a hollow-fiber-like organic nanotube; collecting the organic nanotube from the solution; and air-drying the organic nanotube at room temperature or drying the organic nanotube by heating under reduced pressure. G-NHCO-R<SUP>1</SUP> (1) [wherein G represents a sugar residue produced by removing a hemiacetal hydroxyl group binding to an anomeric carbon atom in a sugar; and R<SUP>1</SUP> represents an unsaturated hydrocarbon group having 10 to 39 carbon atoms] R<SUP>2</SUP>CO(NH-CHR<SUP>3</SUP>-CO)<SUB>m</SUB>OH (2) H(NH-CHR<SUP>3</SUP>-CO)<SUB>m</SUB>NHR<SUP>2</SUP> (3) [wherein R<SUP>2</SUP> represents a hydrocarbon group having 6 to 24 carbon atoms; R<SUP>3</SUP> represents an amino acid side chain; and m represents an integer of 1 to 10]