CHOLESTEROL-REGULATING COMPLEX OF SIRT1 AND LXR AND METHODS OF USE

摘要

A cholesterol-regulating complex of SIRT1 and LXR and methods of use are disclosed. SIRTl forms a complex with LXR bound to an LXR element. Methods o f forming the complex, identifying an agent that modulates formation of the complex, increasing the ratio of cholesterol bound to high density lipoprote in (HDL) to total cholesterol in the plasma of a mammal, promoting ABCA1 -me diated cholesterol efflux from a mammalian cell, treating a subject deemed t o have a level of SIRT1 activity that is below normal, assessing whether a c andidate substance modulates an LXR-dependent process, and assessing whether a candidate substance modulates an SIRTl -dependent effect of an LXR are di sclosed.