MATERIALS AND METHODS FOR IMPROVED MICROBIAL PRODUCTION OF ORGANIC COMPOUNDS

摘要

In accordance with the subject invention, osmoprotectants, such as betaine, may be used to increase the productivity and titer of anaerobic and aerobic fermentation with E. coli. and other microbes. Betaine serves as a protective osmolyte during fermentations with high concentrations of sugars or products, replacing the need to divert carbon and energy into native osmoprotectants such as glutamate and trehalose. Thus, in accordance with the subject invention, betaine and/or other osmoprotectants can be added to media and improve the rates of biological conversion of sugars into chemicals such as organic acids.