| 摘要 |
The present invention relates to Thiadiaz.sigma.le Compounds having, for examples the Formula; compositions comprising an effective dose of a Thiadia zole Compound; and methods treating or preventing a metalloproteinase- relat ed disorder, such as, an arthritic disorder, osteoarthritis, cancer, rheumat oid arthritis, asthma, chronic obstructive pulmonary disease, atherosclerosi s, age- related macular degeneration, myocardial infarction, a corneal ulcer ation, an ocular surface disease, hepatitis, an aortic aneurysm, tendonitis, a central nervous system disorder, abnormal wound healing, angiogenesis, re stenosis, cirrhosis, multiple sclerosis, glomerulonephritis, graft versus ho st disease, diabetes, an inflammatory bowel disease, shock, invertebral disc degeneration, stroke, osteopenia or a periodontal disease or comprising adm inistering- an effective dose of a Thiadiazole Compound to a mammal in need thereof.
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