The present invention relates to a process for the preparation of steroidal 17ß-carboxylic thioates. More particularly the present invention relates to a convenient and efficient synthesis of steroidal 17ß-carboxylic thioates, such as fluticasone propionate formula (I), using soluble mixed fluorides to introduce fluorine by displacing an appropriate leaving group X in compounds formula (II) resulting in selective and controlled fluorination. The present invention also relates to intermediates formula (II) and their preparation.
申请公布号
WO2007144668(A2)
申请公布日期
2007.12.21
申请号
WO2007GB50328
申请日期
2007.06.11
申请人
GENERICS [UK] LIMITED;MERCK DEVELOPMENT CENTRE PRIVATE LIMITED;GORE, VINAYAK G.;GADAKAR, MAHESH;POKHARKAR, K.;WAKCHURE, V.
发明人
GORE, VINAYAK G.;GADAKAR, MAHESH;POKHARKAR, K.;WAKCHURE, V.