发明名称 |
PROMOTER POLYMORPHISMS OF THE BLYS GENE AND USE IN DIAGNOSTIC METHODS |
摘要 |
The present invention provides an isolated polynucleotide comprising at least one polymorphic nucleotide sequence, for example, at position -871 from the promoter region of the BLyS gene, and diagnostic assays for detecting the presence of this polymorphism associated with a condition associated with BLyS activity, such as hematological malignancy including B cell malignancies. The diagnostic assays are useful in predicting an individual's likelihood of developing a condition associated with BLyS activity, such as hematological malignancies, and for methods for treating an individual clinically diagnosed with a condition associated with BLyS activity, such as prediction of a patient's likelihood to respond to a specific drug treatment. The invention also provides an array of nucleic acid molecules immobilized on a solid surface, where at least one of the nucleic acid molecules comprises a BLyS polymorphic nucleic acid molecule. The nucleic acid arrays of the invention allow rapid detection of hybridizing nucleic acid-molecules, in a nucleic acid sample from an individual, of a BLyS polymorphism associated with hematological malignancy. |
申请公布号 |
WO2007053732(A3) |
申请公布日期 |
2007.12.21 |
申请号 |
WO2006US42766 |
申请日期 |
2006.11.01 |
申请人 |
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH;ANSELL, STEPHEN, M.;NOVAK, ANNE, J. |
发明人 |
ANSELL, STEPHEN, M.;NOVAK, ANNE, J. |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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地址 |
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