| 摘要 |
<p>A cancer sensitizer is provided to make cancer cells highly sensitive to anticancer agents without side effects in contrast to conventional chemical sensitizers by comprising glucosamine which is a natural material, or glucosamine derivatives. A cancer sensitizer comprises glucosamine, a glucosamine derivative or a salt thereof, wherein the glucosamine derivative is represented by the formula(2). In the formula(2), R is an acyl group having 2 to 18 carbon atoms or a straight or branched alkyl group having 1 to 5 carbon atoms. A composition for inhibiting chemoresistance comprises glucosamine, a glucosamine derivative, or a salt thereof, and a pharmaceutically acceptable carrier. An anticancer composition comprises the composition for inhibiting chemoresistance and an anticancer agent selected from the group consisting of mechlorethamine, chlorambucil, phenylalanine, mustard, cyclophosphamide, ifosfamide, carmustine(BCNU), lomustine(CCNU), streptozotocin, busulfan, thiotepa, cisplatin, carboplatin, dactinomycin(actinomycin D), doxorubicin(adriamycin), daunorubicin, idarubicin, mitoxantrone, plicamycin, mitomycin, C bleomycin, vincristine, vinblastine, paclitaxel, docetaxel, etoposide, teniposide, topotecan and irinotecan. A method for overcoming chemoresistance comprises a step of administering the cancer sensitizer or the composition for inhibiting chemoresistance.</p> |
