GENE THERAPY FOR AMYOTROPHIC LATERAL SCLEROSIS AND OTHER SPINAL CORD DISORDERS
摘要
This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the invention a transgene product is delivered to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the brain. The viral vector delivers the transgene to a region of the brain which is susceptible to infection by the virus and which expresses the encoded recombinant viral gene product. Also provided are compositions for delivery of a transgene product to a subject's spinal cord by administering a recombinant neurotrophic viral vector containing the transgene to the subject's brain.
申请公布号
WO2007146046(A2)
申请公布日期
2007.12.21
申请号
WO2007US13391
申请日期
2007.06.07
申请人
GENZYME CORPORATION;DODGE, JAMES;SHIHABUDDIN, LAMYA;O'RIORDAN, CATHERINE, R.
发明人
DODGE, JAMES;SHIHABUDDIN, LAMYA;O'RIORDAN, CATHERINE, R.