A method for preventing and treating a renal1 disorder in a human or non-human animal is disclosed. The method involves administering 20-HETE or a 20-HETE agonist to the human or non- human animal in an amount sufficient to prevent or treat the renal disorder. Further disclosed is a method for preventing or treating ischemic acute renal failure in particular wherein the method involves administering 20-HETE or a 20-HETE agonist to the human or non-human animal in an amount sufficient to prevent or treat ischemic acute renal failure. A method for preventing or reducing the severity of damage to an ex vivo preserved kidney upon reperfusion is also disclosed. The method involves preserving the kidney ex vivo in a storage solution that contains 20-HETE or a 20-HETE agonist in an amount sufficient to prevent or reduce the severity of damage to the kidney upon reperfusion.
申请公布号
WO2007146262(A2)
申请公布日期
2007.12.21
申请号
WO2007US13740
申请日期
2007.06.12
申请人
MCW RESEARCH FOUNDATION, INC.;ROMAN, RICHARD J.;DAHLY-VERNON, ANNETTE J.;SHARMA, MUKUT
发明人
ROMAN, RICHARD J.;DAHLY-VERNON, ANNETTE J.;SHARMA, MUKUT