CODON-OPTIMIZED DNA MOLECULES ENCODING THE RECEPTOR BINDING DOMAINS OF CLOSTRIDIUM DIFFICILE TOXINS A AND B, AND METHODS OF USE THEREOF

摘要

In one aspect, the invention provides a DNA molecule. The DNA molecule includes a nucleotide sequence that encodes the receptor-binding domain of Clostridium difficile toxin A or toxin B in which at least about 10% of the in-frame codons for each amino acid residue has a higher percentage use in the human genome than the corresponding in-frame codons of C.difficile toxin A or toxin B having a known sequence. Methods for generating antibodies to Clostridium difficile toxin A or toxin B, methods for reducing the risk of a C.difficile infection, and methods for treating a C. difficile are also provided.