NEW SUPPORTED OXIDATION REACTANTS, PROCESS FOR THEIR PREPARATION AND USES THEREOF

摘要

The present invention relates to a supported oxidation reactant of formul a (I): R-[Met(O)k]n-X- (I) in which: - R represents a hydrogen atom or an am ine function-protecting group, -[Met(O)] represents an oxidized methionine r esidue of formula - k is 1 or 2 - represents a solid or soluble support used in organic synthesis, - X represents a radical derived from a function of t he type amine or hydroxyl, or halogeno, capable of anchoring methionine, it being understood that this function capable of anchoring methionine can be s eparated from the support by means of a functionalized arm or a spacer, and - n is an integer greater than or equal to 1. The invention also relates to the use of a supported oxidation reactant of formula (I), for the formation of intramolecular disulfide bridges, in particular in peptides and/or protei ns.