DPH2 GENE DELETION MUTANT AND USES THEREOF

摘要

Diphtheria and Pseudomonas infections are very common worldwide. The toxi ns involved in the pathogenesis of those diseases act by inactivating the el ongation factor-2 (EF-2), therefore blocking protein synthesis and leading t o cell death. Diphthamide formation on EF-2 is a prerequisite step in the in activation of EF-2, and Dph proteins have been identified as modulating this process. The present application concerns Dph2 deletion mutant genes and pr oteins and their uses in vitro and in vivo.