COMPOSITIONS AND METHODS FOR IDENTIFYING INHIBITORS AND ACTIVATORS OF CYCLIC AMP PHOSPHODIESTERASES

摘要

Recombinant fission yeast cells and methods of using them are described, which provide for identification of chemical inhibitors or activators of a target exogenous phosphodiesterase (PDE). The yeast cells can be transformed using a cDNA library to identify biological inhibitors or activators of PDEs from specific cell types.