ANGIOPOIETIN-LIKE 2 AS A BIOMARKER OF VASCULAR ENDOTHELIAL CELL ABNORMAL FUNCTION AND SENESCENCE

摘要

A method for assessing a physiological state of a mammal. The method includes: obtaining from the mammal a biological sample; measuring the expression of angiopoietin-like 2 in the biological sample; an d assessing the physiological state of the mammal by comparing the measured expression of the angiopoietin-like 2 to a predetermined normal expression level in normal subjects, wherein an increase in angiopoietin-like 2 level over the predetermined normal expression level indicates an abnormal physiologica l state.