| 摘要 |
FIELD: peptides, medicine, immunology. ^ SUBSTANCE: invention relates to novel methods for producing family of antigenic peptides possessing antiviral effect, and to peptide libraries obtained by using indicated methods, and to compositions based on thereof. Method for producing antigenic peptides involves detection of a great number of variable positions in protein site of pathogenic organism; selection of peptide sequence in protein of pathogenic organism comprising a great number of variable positions; selection of one or more substituting amino acid residues for one of variable positions or sequences possessing antigenic affinity with amino acid residues in variable position of this protein in natural conditions by using a matrix of antigenic similarity of amino acids showing possibility for substitution of one amino acid residue with another residue and with retaining interaction of antibody with antigen and corrected in correspondence with amino acids frequencies in hypervariable sites; incorporation of selected substituting amino acid residues into peptide sequence; synthesis of family of antigenic peptides. Also, invention relates to a method for calling the immune response and to a method for diagnosis of HIV-infection by using family of peptides prepared according to methods of the invention. ^ EFFECT: valuable biological and medicinal properties of peptides, improved preparing method. ^ 233 cl, 43 tbl, 1 dwg, 5 ex |
